CDC20 Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. Belongs to the WD repeat CDC20/Fizzy family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 4|4 D2.1
Cellular Component:  centrosome; cytoplasm; cytoskeleton; cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-containing complex
Molecular Function:  anaphase-promoting complex binding; enzyme binding; histone deacetylase binding; protein binding; protein C-terminus binding; ubiquitin-protein transferase activator activity
Biological Process:  anaphase-promoting complex-dependent catabolic process; cell cycle; cell differentiation; cell division; mitotic sister chromatid cohesion; mitotic spindle assembly; nervous system development; positive regulation of cell proliferation; positive regulation of synapse maturation; positive regulation of synaptic plasticity; positive regulation of ubiquitin protein ligase activity; regulation of dendrite development; regulation of meiotic nuclear division
Reference #:  Q9JJ66 (UniProtKB)
Alt. Names/Synonyms: 2310042N09Rik; C87100; Cdc20; cell division cycle 20; cell division cycle 20 homolog; cell division cycle 20 homolog (S. cerevisiae); Cell division cycle protein 20 homolog; mmCdc20; OTTMUSP00000009177; p55CD; p55CDC
Gene Symbols: Cdc20
Molecular weight: 54,816 Da
Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene