CDC20 Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. Belongs to the WD repeat CDC20/Fizzy family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of human Ortholog: 1p34.2
Cellular Component:  centrosome; cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; spindle; spindle pole
Molecular Function:  anaphase-promoting complex binding; enzyme binding; histone deacetylase binding; protein binding; protein C-terminus binding; ubiquitin-protein transferase activator activity
Biological Process:  anaphase-promoting complex-dependent catabolic process; cell division; mitotic sister chromatid cohesion; mitotic spindle assembly; mitotic spindle assembly checkpoint; positive regulation of cell proliferation; positive regulation of synapse maturation; positive regulation of synaptic plasticity; positive regulation of ubiquitin protein ligase activity; protein deubiquitination; protein ubiquitination; regulation of dendrite development; regulation of meiotic nuclear division; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process
Reference #:  Q12834 (UniProtKB)
Alt. Names/Synonyms: bA276H19.3; CDC20; CDC20 cell division cycle 20 homolog; CDC20A; cell division cycle 20; cell division cycle 20 homolog; cell division cycle 20 homolog (S. cerevisiae); Cell division cycle protein 20 homolog; MGC102824; p55CDC
Gene Symbols: CDC20
Molecular weight: 54,723 Da
Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CDC20

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene