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CDC20
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. Belongs to the WD repeat CDC20/Fizzy family. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Ubiquitin conjugating system |
| Chromosomal Location of human Ortholog: 1p34.2 |
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Cellular Component:
centrosome; cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; spindle; spindle pole
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Molecular Function:
anaphase-promoting complex binding; enzyme binding; histone deacetylase binding; protein binding; protein C-terminus binding; ubiquitin-protein transferase activator activity
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Biological Process:
anaphase-promoting complex-dependent catabolic process; cell division; mitotic sister chromatid cohesion; mitotic spindle assembly; mitotic spindle assembly checkpoint; positive regulation of cell proliferation; positive regulation of synapse maturation; positive regulation of synaptic plasticity; positive regulation of ubiquitin protein ligase activity; protein deubiquitination; protein ubiquitination; regulation of dendrite development; regulation of meiotic nuclear division; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process
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Reference #:
Q12834
(UniProtKB)
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Alt. Names/Synonyms: bA276H19.3; CDC20; CDC20 cell division cycle 20 homolog; CDC20A; cell division cycle 20; cell division cycle 20 homolog; cell division cycle 20 homolog (S. cerevisiae); Cell division cycle protein 20 homolog; MGC102824; p55CDC
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Gene Symbols: CDC20
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Molecular weight:
54,723 Da
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Basal Isoelectric point:
9.33
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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