CDC20 Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. Belongs to the WD repeat CDC20/Fizzy family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of human Ortholog: 1p34.2
Cellular Component:  anaphase-promoting complex; cytosol; kinetochore; microtubule organizing center; mitotic checkpoint complex; nucleoplasm; spindle; spindle pole
Molecular Function:  anaphase-promoting complex binding; protein binding; ubiquitin ligase activator activity
Biological Process:  anaphase-promoting complex-dependent catabolic process; cell differentiation; cell division; mitotic sister chromatid cohesion; mitotic spindle assembly; mitotic spindle assembly checkpoint signaling; negative regulation of ubiquitin-protein transferase activity; nervous system development; positive regulation of anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; positive regulation of synapse maturation; positive regulation of synaptic plasticity; positive regulation of ubiquitin protein ligase activity; protein ubiquitination; regulation of meiotic cell cycle; regulation of meiotic nuclear division; regulation of mitotic cell cycle
Disease: Oocyte Maturation Defect 14
Reference #:  Q12834 (UniProtKB)
Alt. Names/Synonyms: bA276H19.3; CDC20; CDC20 cell division cycle 20 homolog; CDC20A; cell division cycle 20; cell division cycle 20 homolog; cell division cycle 20 homolog (S. cerevisiae); Cell division cycle protein 20 homolog; MGC102824; p55CDC
Gene Symbols: CDC20
Molecular weight: 54,723 Da
Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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