CACNA1B Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily. Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 2 A3|2 16.58 cM
Cellular Component:  axon terminus; dendrite; dendritic shaft; glutamatergic synapse; integral component of membrane; membrane; neuron projection; neuronal cell body; plasma membrane; protein-containing complex; Schaffer collateral - CA1 synapse; voltage-gated calcium channel complex
Molecular Function:  ATP binding; calcium channel activity; calcium ion binding; high voltage-gated calcium channel activity; ion channel activity; metal ion binding; nucleotide binding; protein binding; protein C-terminus binding; protein phosphatase 2A binding; voltage-gated calcium channel activity; voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels; voltage-gated ion channel activity
Biological Process:  calcium ion import; calcium ion transmembrane transport; calcium ion transport; chemical synaptic transmission; ion transport; locomotory behavior; modulation of chemical synaptic transmission; neurotransmitter secretion; positive regulation of neurotransmitter secretion; regulation of blood pressure; regulation of calcium ion transport; regulation of heart contraction; regulation of ion transmembrane transport; response to amyloid-beta; response to organic cyclic compound; response to pain; response to testosterone; sensory perception of pain; transmembrane transport
Reference #:  O55017 (UniProtKB)
Alt. Names/Synonyms: alpha(1B); AW050276; AW060892; AW822256; BIII; Brain calcium channel III; CAC1B; Cach5; Cacna1b; Cacnl1a5; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide isoform 5; calcium channel, voltage-dependent, L type, alpha 1B subunit; calcium channel, voltage-dependent, N type, alpha 1B subunit; Cav2.2; Cchn1a; OTTMUSP00000012891; OTTMUSP00000013173; Voltage-dependent N-type calcium channel subunit alpha-1B; Voltage-gated calcium channel subunit alpha Cav2.2
Gene Symbols: Cacna1b
Molecular weight: 261,481 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene