CACNA1B Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily. Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component:  dendrite; neuronal cell body; plasma membrane; presynapse; voltage-gated calcium channel complex
Molecular Function:  amyloid-beta binding; ATP binding; calcium ion binding; high voltage-gated calcium channel activity; protein binding; protein C-terminus binding
Biological Process:  calcium ion transmembrane transport; locomotory behavior; membrane depolarization; modulation of chemical synaptic transmission; neurotransmitter secretion; regulation of blood pressure; regulation of calcium ion transport; regulation of heart contraction; regulation of ion transmembrane transport; response to amyloid-beta; response to pain
Disease: Neurodevelopmental Disorder With Seizures And Nonepileptic Hyperkinetic Movements
Reference #:  Q00975 (UniProtKB)
Alt. Names/Synonyms: BIII; Brain calcium channel III; CAC1B; CACH5; CACNA1B; CACNL1A5; CACNN; calcium channel alpha12.2 subunit; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide isoform 5; calcium channel, N type; calcium channel, voltage-dependent, alpha 1B subunit, N type; calcium channel, voltage-dependent, L type, alpha 1B subunit; calcium channel, voltage-dependent, N type, alpha 1B subunit; Cav2.2; Cav2.2 voltage-gated Ca2+ channel; Voltage-dependent N-type calcium channel subunit alpha-1B; voltage-gated calcium channel alpha subunit Cav2.2; Voltage-gated calcium channel subunit alpha Cav2.2
Gene Symbols: CACNA1B
Molecular weight: 262,496 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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