Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily. Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Molecular Function: amyloid-beta binding; ATP binding; calcium ion binding; high voltage-gated calcium channel activity; protein binding; protein C-terminus binding
Biological Process: calcium ion transmembrane transport; locomotory behavior; membrane depolarization; modulation of chemical synaptic transmission; neurotransmitter secretion; regulation of blood pressure; regulation of calcium ion transport; regulation of heart contraction; regulation of ion transmembrane transport; response to amyloid-beta; response to pain