ZFP42 Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal. Belongs to the krueppel C2H2-type zinc-finger protein family. Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding
Chromosomal Location of Human Ortholog: 4q35.2
Cellular Component:  cytoplasm
Molecular Function:  DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding
Biological Process:  female gonad development; male gonad development; meiotic cell cycle; regulation of transcription by RNA polymerase II
Reference #:  Q96MM3 (UniProtKB)
Alt. Names/Synonyms: hREX-1; Reduced expression protein 1; REX-1; REX1; REX1 transcription factor; Zfp-42; ZFP42; Zinc finger protein 42 homolog; zinc finger protein 42 homolog (mouse); Zinc finger protein 754; ZNF754
Gene Symbols: ZFP42
Molecular weight: 34,802 Da
Basal Isoelectric point: 9.12  Predict pI for various phosphorylation states
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ZFP42

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein