CK2A2 Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily. Note: This description may include information from UniProtKB.

Protein type: CK2 family; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of human Ortholog: 16q21

Cellular Component: acrosomal vesicle; chromatin; cytosol; nucleoplasm; nucleus; protein kinase CK2 complex

Molecular Function: ATP binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity

Biological Process: apoptotic process; cell cycle; cerebral cortex development; liver regeneration; negative regulation of apoptotic signaling pathway; negative regulation of ubiquitin-dependent protein catabolic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; protein phosphorylation; regulation of chromosome separation; spermatogenesis; Wnt signaling pathway

Reference #: P19784 (UniProtKB)

Alt. Names/Synonyms: casein kinase 2 alpha 2; casein kinase 2 alpha'; casein kinase 2, alpha prime polypeptide; Casein kinase II subunit alpha'; CK II alpha'; CK2A2; CK2alpha'; CSK22; CSNK2A1; CSNK2A2; FLJ43934

Gene Symbols: CSNK2A2

Molecular weight: 41,213 Da

Basal Isoelectric point: 8.65 Predict pI for various phosphorylation states

CST Pathways: Adherens Junction Dynamics | NF-kB Signaling

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CK2A2

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