USP34 Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Belongs to the peptidase C19 family. Expressed in brain at low level. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 2p15
Cellular Component:  cytosol
Molecular Function:  cysteine-type endopeptidase activity; protein binding; thiol-dependent ubiquitin-specific protease activity; thiol-dependent ubiquitinyl hydrolase activity
Biological Process:  positive regulation of canonical Wnt signaling pathway; protein deubiquitination; protein K48-linked deubiquitination; ubiquitin-dependent protein catabolic process; Wnt signaling pathway
Reference #:  Q70CQ2 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme 34; FLJ43910; KIAA0570; KIAA0729; MGC104459; Ubiquitin carboxyl-terminal hydrolase 34; ubiquitin specific peptidase 34; ubiquitin specific protease 34; Ubiquitin thioesterase 34; Ubiquitin-specific-processing protease 34; UBP34; USP34
Gene Symbols: USP34
Molecular weight: 404,233 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene