TRIM29 Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation. Expressed in placenta, prostate and thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component:  lysosome
Molecular Function:  DNA-binding transcription factor activity; identical protein binding; p53 binding; protein binding; zinc ion binding
Biological Process:  cell-cell adhesion; innate immune response; negative regulation of protein localization to nucleus; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II
Reference #:  Q14134 (UniProtKB)
Alt. Names/Synonyms: Ataxia telangiectasia group D-associated protein; ataxia-telangiectasia group D-associated protein; ATDC; FLJ36085; TRI29; TRIM29; tripartite motif containing 29; tripartite motif protein TRIM29; tripartite motif-containing 29; Tripartite motif-containing protein 29
Gene Symbols: TRIM29
Molecular weight: 65,835 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TRIM29

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene