syntenin Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell adhesion; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 8q12.1
Cellular Component:  adherens junction; azurophil granule lumen; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum membrane; extracellular exosome; extracellular region; focal adhesion; interleukin-5 receptor complex; intracellular membrane-bounded organelle; melanosome; membrane; membrane raft; nuclear membrane; nucleoplasm; nucleus; plasma membrane
Molecular Function:  cytoskeletal adaptor activity; frizzled binding; identical protein binding; interleukin-5 receptor binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein heterodimerization activity; protein N-terminus binding; syndecan binding
Biological Process:  actin cytoskeleton organization; chemical synaptic transmission; ephrin receptor signaling pathway; intracellular signal transduction; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of receptor internalization; neutrophil degranulation; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of epithelial to mesenchymal transition; positive regulation of exosomal secretion; positive regulation of extracellular exosome assembly; positive regulation of JNK cascade; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; protein targeting to membrane; regulation of mitotic cell cycle; substrate-dependent cell migration, cell extension
Reference #:  O00560 (UniProtKB)
Alt. Names/Synonyms: MDA-9; MDA9; melanoma differentiation associated protein-9; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; Scaffold protein Pbp1; SDCB1; SDCBP; ST1; SYCL; syndecan binding protein (syntenin); Syndecan-binding protein 1; Syntenin-1; TACIP18
Gene Symbols: SDCBP
Molecular weight: 32,444 Da
Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states
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syntenin

Protein Structure Not Found.


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