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STAM1
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Belongs to the STAM family. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 10p12.33 |
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Cellular Component:
cytosol; early endosome membrane; ESCRT-0 complex; intracellular membrane-bounded organelle
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Molecular Function:
phosphatidylinositol binding; protein binding; ubiquitin binding; ubiquitin-like protein ligase binding
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Biological Process:
macroautophagy; membrane fission; multivesicular body assembly; positive regulation of exosomal secretion; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; regulation of extracellular exosome assembly; signal transduction
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Reference #:
Q92783
(UniProtKB)
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Alt. Names/Synonyms: DKFZp686J2352; HSE1 homolog; Signal transducing adapter molecule 1; signal transducing adaptor molecule; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; STAM; STAM-1; STAM1
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Gene Symbols: STAM
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Molecular weight:
59,180 Da
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Basal Isoelectric point:
4.7
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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