SPATA2 Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD. Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD. Belongs to the SPATA2 family. Present at high level in Sertoli cells, but not detected in spermatogenic cells (at protein level) (PubMed:10222154, PubMed:11079456). Low expression in spleen, thymus and prostate (PubMed:10222154). Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of human Ortholog: 20q13.13
Cellular Component:  cytoplasm; fibrillar center; nucleus
Molecular Function:  protein binding
Biological Process:  multicellular organism development; programmed cell death; protein K63-linked deubiquitination; protein linear deubiquitination; regulation of inflammatory response; regulation of necroptotic process; regulation of tumor necrosis factor-mediated signaling pathway; spermatogenesis
Reference #:  Q9UM82 (UniProtKB)
Alt. Names/Synonyms: FLJ13167; KIAA0757; PD1; PPP1R145; protein phosphatase 1, regulatory subunit 145; SPAT2; SPATA2; spermatogenesis associated 2; spermatogenesis associated PD1; Spermatogenesis-associated protein 2; Spermatogenesis-associated protein PD1; tamo
Gene Symbols: SPATA2
Molecular weight: 58,427 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
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SPATA2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein