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SPATA2
Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD. Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD. Belongs to the SPATA2 family. Present at high level in Sertoli cells, but not detected in spermatogenic cells (at protein level) (PubMed:10222154, PubMed:11079456). Low expression in spleen, thymus and prostate (PubMed:10222154). Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of human Ortholog: 20q13.13 |
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Cellular Component:
cytoplasm; cytosol; fibrillar center; nucleoplasm
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Molecular Function:
protein binding; protein-containing complex binding; signaling receptor complex adaptor activity; ubiquitin-specific protease binding
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Biological Process:
necroptotic process; protein K63-linked deubiquitination; protein linear deubiquitination; regulation of inflammatory response; regulation of necroptotic process; regulation of tumor necrosis factor-mediated signaling pathway; seminiferous tubule development; spermatogenesis
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Reference #:
Q9UM82
(UniProtKB)
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Alt. Names/Synonyms: FLJ13167; KIAA0757; PD1; PPP1R145; protein phosphatase 1, regulatory subunit 145; SPAT2; SPATA2; spermatogenesis associated 2; spermatogenesis associated PD1; Spermatogenesis-associated protein 2; Spermatogenesis-associated protein PD1; tamo
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Gene Symbols: SPATA2
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Molecular weight:
58,427 Da
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Basal Isoelectric point:
9
Predict pI for various phosphorylation states
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