SMC5 Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome. Belongs to the SMC family. SMC5 subfamily. Widely expressed (PubMed:11408570). Strongly expressed in testis (PubMed:11408570). Note: This description may include information from UniProtKB.
Protein type: DNA replication
Chromosomal Location of human Ortholog: 9q21.12
Cellular Component:  cell junction; chromosome, telomeric region; interchromatin granule; nuclear speck; nucleoplasm; nucleus; PML body; sex chromosome; site of double-strand break; Smc5-Smc6 complex
Molecular Function:  ATP binding; protein binding
Biological Process:  cell division; cellular response to DNA damage stimulus; cellular senescence; double-strand break repair via homologous recombination; positive regulation of chromosome segregation; positive regulation of maintenance of mitotic sister chromatid cohesion; sister chromatid cohesion; telomere maintenance via recombination
Reference #:  Q8IY18 (UniProtKB)
Alt. Names/Synonyms: hSMC5; KIAA0594; SMC protein 5; SMC-5; SMC5; SMC5 structural maintenance of chromosomes 5-like 1; SMC5L1; structural maintenance of chromosomes 5; Structural maintenance of chromosomes protein 5
Gene Symbols: SMC5
Molecular weight: 128,806 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene