SLC20A2 Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not significantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Ubiquitously expressed. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 8p11.21
Cellular Component:  membrane; plasma membrane
Molecular Function:  signaling receptor activity; sodium:phosphate symporter activity; virus receptor activity
Biological Process:  ion transport; sodium ion transmembrane transport; viral entry into host cell
Disease: Basal Ganglia Calcification, Idiopathic, 1
Reference #:  Q08357 (UniProtKB)
Alt. Names/Synonyms: epididymis secretory sperm binding protein; Gibbon ape leukemia virus receptor 2; GLVR-2; GLVR2; hPit2; IBGC1; IBGC2; IBGC3; MLVAR; murine leukemia virus, amphotropic; murine leukemia virus, amphotropic, receptor for; Phosphate transporter 2; PiT-2; PIT2; Ram-1; RAM1; receptor; S20A2; SLC20A2; Sodium-dependent phosphate transporter 2; solute carrier family 20 (phosphate transporter), member 2; Solute carrier family 20 member 2
Gene Symbols: SLC20A2
Molecular weight: 70,392 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB