CK1G2 Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. Testis. Note: This description may include information from UniProtKB.
Protein type: CK1 group; CK1 family; EC 2.7.11.1; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 19p13.3
Cellular Component:  cell cortex; cytoplasm; cytosol; nucleus; plasma membrane
Molecular Function:  ATP binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  endocytosis; peptidyl-serine phosphorylation; positive regulation of canonical Wnt signaling pathway; protein phosphorylation; signal transduction; sphingolipid biosynthetic process; Wnt signaling pathway
Reference #:  P78368 (UniProtKB)
Alt. Names/Synonyms: casein kinase 1 gamma 2; casein kinase 1 isoform gamma-2; casein kinase 1, gamma 2; casein kinase I; Casein kinase I isoform gamma-2; CK1g2; CKI-gamma 2; CSNK1G2; KC1G2
Gene Symbols: CSNK1G2
Molecular weight: 47,457 Da
Basal Isoelectric point: 9.16  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling  |  Wnt/ß-Catenin Signaling
Select Structure to View Below

CK1G2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB