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CK1G2
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. Testis. Note: This description may include information from UniProtKB.
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| Protein type: CK1 group; CK1 family; EC 2.7.11.1; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 19p13.3 |
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Cellular Component:
cell cortex; cytoplasm; cytosol; nucleus; plasma membrane
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Molecular Function:
ATP binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
endocytosis; peptidyl-serine phosphorylation; positive regulation of canonical Wnt signaling pathway; protein phosphorylation; signal transduction; sphingolipid biosynthetic process; Wnt signaling pathway
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Reference #:
P78368
(UniProtKB)
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Alt. Names/Synonyms: casein kinase 1 gamma 2; casein kinase 1 isoform gamma-2; casein kinase 1, gamma 2; casein kinase I; Casein kinase I isoform gamma-2; CK1g2; CKI-gamma 2; CSNK1G2; KC1G2
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Gene Symbols: CSNK1G2
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Molecular weight:
47,457 Da
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Basal Isoelectric point:
9.16
Predict pI for various phosphorylation states
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CST Pathways:
Hedgehog Signaling
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Wnt/ß-Catenin Signaling
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