PTPRK Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 6q22.33
Cellular Component:  adherens junction; axon; cell junction; cell surface; cell-cell junction; dendrite; integral component of membrane; integral component of plasma membrane; intracellular membrane-bounded organelle; leading edge membrane; neuronal cell body; photoreceptor outer segment; plasma membrane
Molecular Function:  beta-catenin binding; gamma-catenin binding; protein binding; protein kinase binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity
Biological Process:  cell adhesion; cell migration; cellular response to reactive oxygen species; cellular response to UV; focal adhesion assembly; negative regulation of cell cycle; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of keratinocyte proliferation; negative regulation of transcription, DNA-templated; neuron projection development; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; protein localization to cell surface; signal transduction; transforming growth factor beta receptor signaling pathway
Reference #:  Q15262 (UniProtKB)
Alt. Names/Synonyms: dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa; DKFZp686C2268; DKFZp779N1045; protein tyrosine phosphatase receptor type K; protein tyrosine phosphatase, receptor type, K; Protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase, receptor type, kappa; PTPK; PTPRK; R-PTP-kappa; Receptor-type tyrosine-protein phosphatase kappa
Gene Symbols: PTPRK
Molecular weight: 162,102 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene