NUF2 Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Belongs to the NUF2 family. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); DNA replication
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component:  chromosome, centromeric region; cytosol; Ndc80 complex; nucleus
Molecular Function:  protein binding
Biological Process:  cell division; chromosome segregation
Reference #:  Q9BZD4 (UniProtKB)
Alt. Names/Synonyms: cancer/testis antigen 106; CDCA1; cell division cycle associated 1; Cell division cycle-associated protein 1; CT106; hNuf2; hNuf2R; hsNuf2; Kinetochore protein Nuf2; NDC80 kinetochore complex component NUF2; NUF2; NUF2 component of NDC80 kinetochore complex; NUF2, NDC80 kinetochore complex component; NUF2, NDC80 kinetochore complex component, homolog; NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae); NUF2R
Gene Symbols: NUF2
Molecular weight: 54,304 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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