LRP6 Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation. Belongs to the LDLR family. Widely coexpressed with LRP5 during embryogenesis and in adult tissues. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 12p13.2
Cellular Component:  cell surface; cytoplasmic vesicle; early endosome membrane; endoplasmic reticulum; extracellular region; integral component of membrane; plasma membrane; Wnt signalosome; Wnt-Frizzled-LRP5/6 complex
Molecular Function:  coreceptor activity involved in canonical Wnt signaling pathway; coreceptor activity involved in Wnt signaling pathway; frizzled binding; identical protein binding; kinase inhibitor activity; low-density lipoprotein particle receptor activity; protein binding; protein homodimerization activity; signaling receptor binding; toxin transmembrane transporter activity; Wnt-activated receptor activity; Wnt-protein binding
Biological Process:  beta-catenin destruction complex disassembly; canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in neural crest cell differentiation; canonical Wnt signaling pathway involved in regulation of cell proliferation; cell-cell adhesion; cellular response to cholesterol; dopaminergic neuron differentiation; midbrain dopaminergic neuron differentiation; negative regulation of canonical Wnt signaling pathway; negative regulation of protein kinase activity; negative regulation of protein phosphorylation; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest cell differentiation; neural crest formation; positive regulation of cell cycle; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA-binding transcription factor activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein localization to plasma membrane; response to peptide hormone; toxin transport; Wnt signaling pathway; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
Disease: Coronary Artery Disease, Autosomal Dominant 2; Tooth Agenesis, Selective, 7
Reference #:  O75581 (UniProtKB)
Alt. Names/Synonyms: ADCAD2; FLJ90062; FLJ90421; LDL receptor related protein 6; low density lipoprotein receptor-related protein 6; Low-density lipoprotein receptor-related protein 6; LRP-6; LRP6; STHAG7
Gene Symbols: LRP6
Molecular weight: 180,429 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB