| LRP6 Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation. Belongs to the LDLR family. Widely coexpressed with LRP5 during embryogenesis and in adult tissues. Note: This description may include information from UniProtKB. |
| Protein type: Membrane protein, integral; Receptor, misc. |
| Chromosomal Location of human Ortholog: 12p13.2 |
| Cellular Component: caveola; cell surface; cytoplasmic vesicle; early endosome; early endosome membrane; endoplasmic reticulum; extracellular region; Golgi apparatus; neuronal cell body; plasma membrane; synapse; Wnt signalosome; Wnt-Frizzled-LRP5/6 complex |
| Molecular Function: coreceptor activity involved in canonical Wnt signaling pathway; coreceptor activity involved in Wnt signaling pathway; frizzled binding; identical protein binding; kinase inhibitor activity; low-density lipoprotein particle receptor activity; protein binding; protein homodimerization activity; signaling receptor binding; toxin transmembrane transporter activity; Wnt receptor activity; Wnt-protein binding |
| Biological Process: canonical Wnt signaling pathway; canonical Wnt signaling pathway involved in neural crest cell differentiation; canonical Wnt signaling pathway involved in regulation of cell proliferation; cell-cell adhesion; cellular response to cholesterol; chemical synaptic transmission; dopaminergic neuron differentiation; midbrain dopaminergic neuron differentiation; negative regulation of protein kinase activity; negative regulation of protein phosphorylation; negative regulation of protein serine/threonine kinase activity; negative regulation of smooth muscle cell apoptotic process; neural crest cell differentiation; neural crest formation; positive regulation of cell cycle; positive regulation of cytosolic calcium ion concentration; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; protein localization to plasma membrane; receptor-mediated endocytosis involved in cholesterol transport; response to peptide hormone; toxin transport; Wnt signaling pathway; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; Wnt signaling pathway involved in somitogenesis |
| Disease: Coronary Artery Disease, Autosomal Dominant 2; Exudative Vitreoretinopathy 8; Tooth Agenesis, Selective, 7 |
| Reference #: O75581 (UniProtKB) |
| Alt. Names/Synonyms: ADCAD2; FLJ90062; FLJ90421; LDL receptor related protein 6; low density lipoprotein receptor-related protein 6; Low-density lipoprotein receptor-related protein 6; LRP-6; LRP6; STHAG7 |
| Gene Symbols: LRP6 |
| Molecular weight: 180,429 Da |
| Basal Isoelectric point: 5.12 Predict pI for various phosphorylation states |
| CST Pathways: ESC Pluripotency and Differentiation | Microtubule Dynamics | mTOR Signaling | Translation: eIF4E and p70S6K | Wnt/ß-Catenin Signaling |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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LRP6 |
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Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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Protein Atlas
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BioGPS
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Pfam
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