K81 Belongs to the intermediate filament family. Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Expressed in malignant lymph node tissue in breast carcinoma tissue. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  cytosol; keratin filament
Molecular Function:  protein binding; structural molecule activity
Biological Process:  cornification; keratinization
Disease: Monilethrix
Reference #:  Q14533 (UniProtKB)
Alt. Names/Synonyms: ghHb1; ghHKb1; Hair keratin K2.9; hard keratin, type II, 1; Hb-1; HB1; hHAKB2-1; K81; keratin 81; keratin 81, type II; Keratin, hair, basic, 1; Keratin, type II cuticular Hb1; Keratin-81; KRT81; KRTHB1; Metastatic lymph node 137 gene protein; MLN 137; MLN137; Type II hair keratin Hb1; Type-II keratin Kb21
Gene Symbols: KRT81
Molecular weight: 54,928 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene