|
CK1E
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes. Note: This description may include information from UniProtKB.
|
| Protein type: CK1 group; CK1 family; CK1-D subfamily; EC 2.7.11.1; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 22q13.1 |
|
Cellular Component:
cytoplasm; cytosol; growth cone; neuronal cell body; nucleoplasm; nucleus; ribonucleoprotein complex
|
|
Molecular Function:
ATP binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity
|
|
Biological Process:
canonical Wnt signaling pathway; cellular response to nerve growth factor stimulus; circadian behavior; circadian regulation of gene expression; DNA repair; endocytosis; negative regulation of protein binding; negative regulation of Wnt signaling pathway; peptidyl-serine phosphorylation; positive regulation of amyloid-beta formation; positive regulation of canonical Wnt signaling pathway; positive regulation of non-canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; protein localization; protein phosphorylation; regulation of circadian rhythm; regulation of protein localization; signal transduction
|
|
Reference #:
P49674
(UniProtKB)
|
|
Alt. Names/Synonyms: casein kinase 1 epsilon; casein kinase 1, epsilon; Casein kinase I isoform epsilon; CK1E; CKI-epsilon; CKIe; CKIepsilon; CSNK1E; HCKIE; KC1E; MGC10398
|
|
Gene Symbols: CSNK1E
|
|
Molecular weight:
47,315 Da
|
|
Basal Isoelectric point:
9.68
Predict pI for various phosphorylation states
|
|
CST Pathways:
Hedgehog Signaling
|
Hippo Signaling
|
Wnt/ß-Catenin Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
