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HSH2
May be a modulator of the apoptotic response through its ability to affect mitochondrial stability. Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 19p13.11 |
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Cellular Component:
cytoplasm; cytosol; mitochondrion; nucleus
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Molecular Function:
protein binding; protein-macromolecule adaptor activity
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Biological Process:
negative regulation of B cell apoptotic process; negative regulation of mitochondrial depolarization; signal transduction; T cell activation
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Reference #:
Q96JZ2
(UniProtKB)
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Alt. Names/Synonyms: Adaptor in lymphocytes of unknown function X; ALX; FLJ14886; hematopoietic SH2 domain containing; Hematopoietic SH2 domain-containing protein; Hematopoietic SH2 protein; HSH2; HSH2D
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Gene Symbols: HSH2D
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Molecular weight:
39,002 Da
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Basal Isoelectric point:
6.64
Predict pI for various phosphorylation states
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