HSH2 May be a modulator of the apoptotic response through its ability to affect mitochondrial stability. Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 19p13.11
Cellular Component:  nucleus
Molecular Function:  protein binding
Biological Process:  signal transduction
Reference #:  Q96JZ2 (UniProtKB)
Alt. Names/Synonyms: Adaptor in lymphocytes of unknown function X; ALX; FLJ14886; hematopoietic SH2 domain containing; Hematopoietic SH2 domain-containing protein; Hematopoietic SH2 protein; HSH2; HSH2D
Gene Symbols: HSH2D
Molecular weight: 39,002 Da
Basal Isoelectric point: 6.64  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene