PIDD Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis. Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B. Ubiquitous. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Cellular Component: 
Reference #:  Q9ERV7 (UniProtKB)
Alt. Names/Synonyms: Leucine-rich repeat and death domain-containing protein; Lrdd; p53-induced death domain-containing protein 1; Pidd; PIDD-C; PIDD-CC; PIDD-N; PIDD1
Gene Symbols: Lrdd
Molecular weight: 101,141 Da
Basal Isoelectric point: 5.96  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Mitochondrial Control of Apoptosis
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PIDD

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  GenPept  |  Ensembl Gene  |  Ensembl Protein