TUBA1A Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. Expressed at a high level in fetal brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 12q13.12
Cellular Component:  condensed chromosome; cytoplasm; cytoplasmic microtubule; cytoplasmic ribonucleoprotein granule; cytosol; microtubule; microtubule cytoskeleton; neuromuscular junction; plasma membrane; recycling endosome
Molecular Function:  GTP binding; hydrolase activity; identical protein binding; metal ion binding; protein binding; protein heterodimerization activity; protein-containing complex binding; structural constituent of cytoskeleton; structural molecule activity
Biological Process:  adult locomotory behavior; cell division; cellular response to calcium ion; centrosome cycle; cerebellar cortex morphogenesis; cerebral cortex development; cytoskeleton-dependent intracellular transport; dentate gyrus development; forebrain morphogenesis; gene expression; glial cell differentiation; homeostasis of number of cells within a tissue; intracellular protein transport; memory; microtubule cytoskeleton organization; microtubule polymerization; microtubule-based process; mitotic cell cycle; motor behavior; neuron apoptotic process; neuron migration; neuron projection arborization; organelle transport along microtubule; regulation of synapse organization; response to L-glutamate; response to mechanical stimulus; response to tumor necrosis factor; smoothened signaling pathway; startle response; synapse organization; visual learning
Disease: Lissencephaly 3
Reference #:  Q71U36 (UniProtKB)
Alt. Names/Synonyms: Alpha-tubulin 3; B-ALPHA-1; Detyrosinated tubulin alpha-1A chain; FLJ25113; hum-a-tub1; hum-a-tub2; LIS3; TBA1A; TUBA1A; TUBA3; tubulin; tubulin alpha 1a; Tubulin alpha-1A chain; Tubulin alpha-3 chain; Tubulin B-alpha-1; tubulin, alpha 1a; tubulin, alpha 3; tubulin, alpha, brain-specific
Gene Symbols: TUBA1A
Molecular weight: 50,136 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene