|
DSG2
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. All of the tissues tested and carcinomas. Note: This description may include information from UniProtKB.
|
| Protein type: Calcium-binding; Cell adhesion; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 18q12.1 |
|
Cellular Component:
apical plasma membrane; cell junction; cell-cell junction; cornified envelope; desmosome; intercalated disc; intracellular membrane-bounded organelle; lateral plasma membrane; plasma membrane
|
|
Molecular Function:
calcium ion binding; cell adhesion molecule binding; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication; protein binding
|
|
Biological Process:
bundle of His cell-Purkinje myocyte adhesion involved in cell communication; cell adhesion; cell-cell adhesion; desmosome organization; homophilic cell adhesion via plasma membrane adhesion molecules; maternal process involved in female pregnancy; Purkinje myocyte development; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; response to progesterone
|
|
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 10; Cardiomyopathy, Dilated, 1bb
|
|
Reference #:
Q14126
(UniProtKB)
|
|
Alt. Names/Synonyms: ARVC10; ARVD10; Cadherin family member 5; CDHF5; CMD1BB; desmoglein 2; Desmoglein-2; DSG2; HDGC; MGC117034; MGC117036; MGC117037
|
|
Gene Symbols: DSG2
|
|
Molecular weight:
122,294 Da
|
|
Basal Isoelectric point:
5.13
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
