Claudin-3 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the claudin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component:  apicolateral plasma membrane; bicellular tight junction; cytoplasm; integral component of membrane; integral component of plasma membrane; lateral plasma membrane
Molecular Function:  identical protein binding; structural molecule activity; transmembrane signaling receptor activity
Biological Process:  bicellular tight junction assembly; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; epithelial cell morphogenesis; protein heterooligomerization; protein homooligomerization; response to ethanol; response to hypoxia
Reference #:  O15551 (UniProtKB)
Alt. Names/Synonyms: C7orf1; claudin 3; Claudin-3; claudin3; CLD3; CLDN3; Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-R2; CPE-receptor 2; CPETR2; hRVP1; Rat ventral prostate.1 protein homolog; RVP1; ventral prostate.1 protein homolog; ventral prostate.1-like protein
Gene Symbols: CLDN3
Molecular weight: 23,319 Da
Basal Isoelectric point: 8.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Claudin-3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB