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Claudin-3
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the claudin family. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of Human Ortholog: 7q11.23 |
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Cellular Component:
apicolateral plasma membrane; bicellular tight junction; cytoplasm; integral component of membrane; integral component of plasma membrane; lateral plasma membrane
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Molecular Function:
identical protein binding; structural molecule activity; transmembrane signaling receptor activity
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Biological Process:
bicellular tight junction assembly; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; epithelial cell morphogenesis; protein heterooligomerization; protein homooligomerization; response to ethanol; response to hypoxia
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Reference #:
O15551
(UniProtKB)
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Alt. Names/Synonyms: C7orf1; claudin 3; Claudin-3; claudin3; CLD3; CLDN3; Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-R2; CPE-receptor 2; CPETR2; hRVP1; Rat ventral prostate.1 protein homolog; RVP1; ventral prostate.1 protein homolog; ventral prostate.1-like protein
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Gene Symbols: CLDN3
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Molecular weight:
23,319 Da
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Basal Isoelectric point:
8.37
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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