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BCAR3
May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 1p22.1 |
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Cellular Component:
cytoplasm; focal adhesion; membrane
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Molecular Function:
guanyl-nucleotide exchange factor activity; kinase binding; phosphotyrosine residue binding; protein binding
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Biological Process:
endothelin receptor signaling pathway; insulin receptor signaling pathway; lens morphogenesis in camera-type eye; positive regulation of DNA replication; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of GTPase activity; positive regulation of MAPK cascade; positive regulation of peptidyl-serine phosphorylation; response to xenobiotic stimulus; signal transduction; small GTPase mediated signal transduction
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Reference #:
O75815
(UniProtKB)
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Alt. Names/Synonyms: AND-34; BCAR3; BCAR3 adaptor protein, NSP family member; BCAR3, NSP family adaptor protein; breast cancer anti-estrogen resistance 3; Breast cancer anti-estrogen resistance protein 3; breast cancer antiestrogen resistance 3 protein; dJ1033H22.2 (breast cancer anti-estrogen resistance 3); epididymis secretory sperm binding protein; KIAA0554; Novel SH2-containing protein 2; NSP2; SH2 domain-containing protein 3B; SH2D3B
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Gene Symbols: BCAR3
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Molecular weight:
92,566 Da
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Basal Isoelectric point:
8.19
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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