BCAR3 a ubiquitously expressed regulator of R-Ras activity that has been implicated in breast cancer. A GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1. Can accelerate the degradation of IRS-1, thus regulating signaling through the insulin receptor. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Up-regulated by interleukin-1-alpha and TNF-beta in thymus cortical reticular cell lines (mouse).Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p22.1
Cellular Component:  intracellular
Molecular Function:  guanyl-nucleotide exchange factor activity; protein binding
Biological Process:  lens morphogenesis in camera-type eye; positive regulation of peptidyl-serine phosphorylation; positive regulation of signal transduction; response to drug; signal transduction; small GTPase mediated signal transduction
Reference #:  O75815 (UniProtKB)
Alt. Names/Synonyms: BCAR3; breast cancer anti-estrogen resistance 3; Breast cancer anti-estrogen resistance protein 3; dJ1033H22.2 (breast cancer anti-estrogen resistance 3); KIAA0554; Novel SH2-containing protein 2; NSP2; SH2 domain-containing protein 3B; SH2D3B
Gene Symbols: BCAR3
Molecular weight: 92,566 Da
Basal Isoelectric point: 8.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BCAR3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene