AKR1B10 Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Displays no reductase activity towards glucose. Belongs to the aldo/keto reductase family. Found in many tissues. Highly expressed in small intestine, colon and adrenal gland. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.-; EC; Lipid Metabolism - linoleic acid; Oxidoreductase
Chromosomal Location of Human Ortholog: 7q33
Cellular Component:  cytosol; extracellular region; lysosome
Molecular Function:  alcohol dehydrogenase (NADP+) activity; aldo-keto reductase (NADP) activity; allyl-alcohol dehydrogenase activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; NADP-retinol dehydrogenase activity; protein binding; retinal dehydrogenase activity
Biological Process:  cellular detoxification of aldehyde; daunorubicin metabolic process; doxorubicin metabolic process; farnesol catabolic process; oxidation-reduction process; retinoid metabolic process; retinol metabolic process
Reference #:  O60218 (UniProtKB)
Alt. Names/Synonyms: AK1BA; AKR1B10; AKR1B11; AKR1B12; Aldo-keto reductase family 1 member B10; aldo-keto reductase family 1, member B10 (aldose reductase); aldo-keto reductase family 1, member B11 (aldose reductase-like); Aldose reductase-like; aldose reductase-like 1; aldose reductase-like peptide; Aldose reductase-related protein; ALDRLn; ARL-1; ARL1; ARP; hARP; HIS; HSI; MGC14103; SI reductase; Small intestine reductase
Gene Symbols: AKR1B10
Molecular weight: 36,020 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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