CLK4 Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. Expressed in liver, kidney, heart, muscle, brain and endothelial cells. Note: This description may include information from UniProtKB.
Protein type: CLK family; CMGC group; EC 2.7.12.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component:  nucleus
Molecular Function:  ATP binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
Biological Process:  peptidyl-tyrosine phosphorylation; protein autophosphorylation; regulation of RNA splicing
Reference #:  Q9HAZ1 (UniProtKB)
Alt. Names/Synonyms: CDC-like kinase 4; CLK4; DKFZp686A20267; Dual specificity protein kinase CLK4; protein serine threonine kinase Clk4
Gene Symbols: CLK4
Molecular weight: 57,492 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
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CLK4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene