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CLK4
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. Expressed in liver, kidney, heart, muscle, brain and endothelial cells. Note: This description may include information from UniProtKB.
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| Protein type: CLK family; CMGC group; EC 2.7.12.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) |
| Chromosomal Location of human Ortholog: 5q35.3 |
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Cellular Component:
nucleus
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Molecular Function:
ATP binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
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Biological Process:
peptidyl-tyrosine phosphorylation; protein autophosphorylation; regulation of RNA splicing
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Reference #:
Q9HAZ1
(UniProtKB)
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Alt. Names/Synonyms: CDC like kinase 4; CDC-like kinase 4; CLK4; DKFZp686A20267; Dual specificity protein kinase CLK4; protein serine threonine kinase Clk4
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Gene Symbols: CLK4
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Molecular weight:
57,492 Da
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Basal Isoelectric point:
8.92
Predict pI for various phosphorylation states
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