ANXA4 Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Belongs to the annexin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Lipid-binding
Chromosomal Location of human Ortholog: 2p13.3
Cellular Component:  cell surface; cytoplasm; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; vesicle membrane
Molecular Function:  calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; identical protein binding; NF-kappaB binding; phospholipase inhibitor activity; protein binding
Biological Process:  epithelial cell differentiation; negative regulation of apoptotic process; negative regulation of catalytic activity; negative regulation of interleukin-8 secretion; negative regulation of NF-kappaB transcription factor activity; regulation of transcription by RNA polymerase II; signal transduction
Reference #:  P09525 (UniProtKB)
Alt. Names/Synonyms: 35-beta calcimedin; Annexin A4; Annexin IV; annexin IV (placental anticoagulant protein II); Annexin-4; ANX4; anxa 4; ANXA4; Carbohydrate-binding protein p33/p41; Chromobindin-4; DKFZp686H02120; Endonexin I; epididymis secretory protein Li 274; HEL-S-274; Lipocortin IV; MGC75105; P32.5; PAP-II; PIG28; Placental anticoagulant protein II; PP4-X; proliferation-inducing gene 28; proliferation-inducing protein 28; Protein II; ZAP36
Gene Symbols: ANXA4
Molecular weight: 35,883 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene