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Alix
Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP. By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier. (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Apoptosis |
| Chromosomal Location of human Ortholog: 3p22.3 |
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Cellular Component:
actomyosin; bicellular tight junction; cytosol; endoplasmic reticulum exit site; endosome; extracellular exosome; Flemming body; immunological synapse; melanosome; microtubule organizing center
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Molecular Function:
calcium-dependent protein binding; protein binding; protein homodimerization activity; proteinase activated receptor binding
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Biological Process:
actomyosin contractile ring assembly; apoptotic process; bicellular tight junction assembly; maintenance of epithelial cell apical/basal polarity; midbody abscission; mitotic cytokinesis; mitotic metaphase plate congression; multivesicular body assembly; nucleus organization; positive regulation of exosomal secretion; positive regulation of extracellular exosome assembly; protein homooligomerization; protein transport; regulation of centrosome duplication; regulation of extracellular exosome assembly; regulation of membrane permeability; regulation of mitotic spindle assembly; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway; viral budding; viral budding via host ESCRT complex
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Disease: Microcephaly 29, Primary, Autosomal Recessive
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Reference #:
Q8WUM4
(UniProtKB)
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Alt. Names/Synonyms: AIP1; ALG-2 interacting protein 1; ALG-2 interacting protein X; ALG-2-interacting protein 1; ALG-2-interacting protein X; ALIX; apoptosis-linked gene 2-interacting protein X; dopamine receptor interacting protein 4; DRIP4; Hp95; KIAA1375; MGC17003; PDC6I; PDCD6-interacting protein; PDCD6IP; programmed cell death 6 interacting protein; Programmed cell death 6-interacting protein
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Gene Symbols: PDCD6IP
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Molecular weight:
96,023 Da
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Basal Isoelectric point:
6.13
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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