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SPRY1
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Belongs to the sprouty family. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 4q28.1 |
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Cellular Component:
cytosol; Golgi apparatus; nucleoplasm; plasma membrane
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Molecular Function:
protein binding
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Biological Process:
animal organ development; bud elongation involved in lung branching; epithelial to mesenchymal transition involved in cardiac fibroblast development; ERK1 and ERK2 cascade; establishment of mitotic spindle orientation; metanephros development; negative regulation of cell population proliferation; negative regulation of epithelial to mesenchymal transition; negative regulation of ERK1 and ERK2 cascade; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of GTPase activity; negative regulation of lens fiber cell differentiation; negative regulation of MAP kinase activity; negative regulation of neurotrophin TRK receptor signaling pathway; negative regulation of Ras protein signal transduction; negative regulation of transforming growth factor beta receptor signaling pathway; organ induction; ureteric bud development
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Reference #:
O43609
(UniProtKB)
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Alt. Names/Synonyms: hSPRY1; Protein sprouty homolog 1; sprouty homolog 1, antagonist of FGF signaling; sprouty homolog 1, antagonist of FGF signaling (Drosophila); sprouty RTK signaling antagonist 1; sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling); Spry-1; SPRY1; SPY1
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Gene Symbols: SPRY1
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Molecular weight:
35,122 Da
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Basal Isoelectric point:
8.65
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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Growth And Differentiation Control by MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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