PLCL2 May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Phospholipase
Chromosomal Location of Human Ortholog: 17|17 C
Cellular Component:  cytoplasm
Molecular Function:  GABA receptor binding; inositol 1,4,5 trisphosphate binding; phosphatidylinositol phospholipase C activity; phosphoric diester hydrolase activity
Biological Process:  B cell proliferation involved in immune response; B-1a B cell differentiation; gamma-aminobutyric acid signaling pathway; inositol trisphosphate biosynthetic process; intracellular signal transduction; lipid metabolic process; negative regulation of B cell receptor signaling pathway; negative regulation of cold-induced thermogenesis; positive regulation of receptor binding; regulation of peptidyl-serine phosphorylation; regulation of synaptic transmission, GABAergic; signal transduction
Reference #:  Q8K394 (UniProtKB)
Alt. Names/Synonyms: Inactive phospholipase C-like protein 2; Kiaa1092; mKIAA1092; phospholipase C, epsilon 2; Phospholipase C-epsilon-2; Phospholipase C-L2; phospholipase C-like 2; Plc; PLC-epsilon-2; PLC-L(2); PLC-L2; Plce2; Plcl2; PRIP-2
Gene Symbols: Plcl2
Molecular weight: 125,772 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below

PLCL2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene