TELO2 Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. Belongs to the TEL2 family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17|17 A3.3
Cellular Component:  ASTRA complex; chromosome; chromosome, telomeric region; cytoplasm; cytosol; membrane; nuclear body; nuclear chromosome, telomeric region; nuclear periphery; nucleus; TORC1 complex; TORC2 complex
Molecular Function:  Hsp90 protein binding; molecular adaptor activity; protein binding; protein kinase binding; protein-containing complex binding; telomeric DNA binding
Biological Process:  positive regulation of protein serine/threonine kinase activity; positive regulation of TORC1 signaling; positive regulation of TORC2 signaling; protein stabilization; regulation of TOR signaling; telomere maintenance
Reference #:  Q9DC40 (UniProtKB)
Alt. Names/Synonyms: 1200003M09Rik; AI415602; Kiaa0683; mKIAA0683; OTTMUSP00000030086; OTTMUSP00000030089; Tel2; TEL2, telomere maintenance 2, homolog; TEL2, telomere maintenance 2, homolog (S. cerevisiae); Telo2; Telomere length regulation protein TEL2 homolog; telomere maintenance 2
Gene Symbols: Telo2
Molecular weight: 93,313 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene