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ZNF183
Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. Ubiquitous. Note: This description may include information from UniProtKB.
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| Protein type: Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of mouse Ortholog: 12|12 D1 |
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Cellular Component:
nucleoplasm; nucleus; U2-type precatalytic spliceosome; U2-type spliceosomal complex
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Molecular Function:
ubiquitin protein ligase activity
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Biological Process:
mRNA splicing, via spliceosome; negative regulation of chemokine-mediated signaling pathway; protein ubiquitination; snoRNA splicing
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Reference #:
Q9D7A3
(UniProtKB)
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Alt. Names/Synonyms: 2310020H19Rik; AI426758; MGC144613; ring finger protein 113A2; Rnf113a; Rnf113a2; Uncharacterized protein; ZNF183
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Gene Symbols: Rnf113a2
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Molecular weight:
39,161 Da
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Basal Isoelectric point:
7.05
Predict pI for various phosphorylation states
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