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ZFAND2B
Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of mouse Ortholog: 1|1 C4 |
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Cellular Component:
cytoplasm; endoplasmic reticulum; membrane; proteasome complex
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Molecular Function:
K48-linked polyubiquitin modification-dependent protein binding; metal ion binding; polyubiquitin modification-dependent protein binding; protein binding; ubiquitin binding; zinc ion binding
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Biological Process:
proteasome-mediated ubiquitin-dependent protein catabolic process; protein targeting to ER; regulation of insulin-like growth factor receptor signaling pathway; SRP-dependent cotranslational protein targeting to membrane, translocation
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Reference #:
Q91X58
(UniProtKB)
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Alt. Names/Synonyms: 1110060O18Rik; AIRAP-like protein; Airapl; AN1-type zinc finger protein 2B; Arsenite-inducible RNA-associated protein-like protein; C81256; Zfand2b; ZFN2B; zinc finger, AN1 type domain 2B
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Gene Symbols: Zfand2b
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Molecular weight:
27,895 Da
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Basal Isoelectric point:
6.5
Predict pI for various phosphorylation states
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