IGJ Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component:  dimeric IgA immunoglobulin complex; extracellular region; extracellular space; monomeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; secretory dimeric IgA immunoglobulin complex; secretory IgA immunoglobulin complex
Molecular Function:  antigen binding; IgA binding; protein binding, bridging; protein homodimerization activity
Biological Process:  adaptive immune response; antibacterial humoral response; glomerular filtration; immune response; innate immune response; leukocyte migration; positive regulation of protein oligomerization; positive regulation of respiratory burst; receptor-mediated endocytosis
Reference #:  P01591 (UniProtKB)
Alt. Names/Synonyms: IGCJ; IGJ; Immunoglobulin J chain; immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides; JCH
Gene Symbols: JCHAIN
Molecular weight: 18,099 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB