MMP11 May play an important role in the progression of epithelial malignancies. Belongs to the peptidase M10A family. Specifically expressed in stromal cells of breast carcinomas. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.-; Extracellular matrix; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 22q11.23
Cellular Component:  extracellular matrix; extracellular region; Golgi lumen
Molecular Function:  zinc ion binding
Biological Process:  basement membrane organization; collagen catabolic process; collagen fibril organization; extracellular matrix disassembly; multicellular organism development; negative regulation of fat cell differentiation; proteolysis
Reference #:  P24347 (UniProtKB)
Alt. Names/Synonyms: matrix metallopeptidase 11; matrix metallopeptidase 11 (stromelysin 3); matrix metalloproteinase 11 (stromelysin 3); Matrix metalloproteinase-11; MMP-11; MMP11; SL-3; ST3; STMY3; stromelysin 3; stromelysin III; Stromelysin-3
Gene Symbols: MMP11
Molecular weight: 54,590 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB