MMP11
May play an important role in the progression of epithelial malignancies. Belongs to the peptidase M10A family. Specifically expressed in stromal cells of breast carcinomas. Note: This description may include information from UniProtKB.
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Protein type: EC 3.4.24.-; Extracellular matrix; Protease; Secreted; Secreted, signal peptide |
Chromosomal Location of human Ortholog: 22q11.23 |
Cellular Component:
extracellular matrix; extracellular region; extracellular space; Golgi lumen
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Molecular Function:
metalloendopeptidase activity; serine-type endopeptidase activity; zinc ion binding
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Biological Process:
basement membrane organization; collagen catabolic process; collagen fibril organization; extracellular matrix disassembly; extracellular matrix organization; negative regulation of fat cell differentiation; proteolysis
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Reference #:
P24347
(UniProtKB)
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Alt. Names/Synonyms: matrix metallopeptidase 11; matrix metallopeptidase 11 (stromelysin 3); matrix metalloproteinase 11 (stromelysin 3); Matrix metalloproteinase-11; MMP-11; MMP11; SL-3; ST3; STMY3; stromelysin 3; stromelysin III; Stromelysin-3
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Gene Symbols: MMP11
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Molecular weight:
54,590 Da
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Basal Isoelectric point:
6.38
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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GPCR Signaling to MAPKs
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