GPR22 Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway. May be involved in ciliogenesis. Belongs to the G-protein coupled receptor 1 family. High expression in adult and fetal heart tissue (PubMed:18539757). Expressed in the brain, with enrichment in the accumbens, amygdala, cerebellum, cortex, and hippocampus regions (PubMed:9073069, PubMed:18539757). Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 7q22.3
Cellular Component:  plasma membrane
Molecular Function:  G protein-coupled receptor activity
Biological Process:  cell projection organization
Reference #:  Q99680 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor 22; G-protein coupled receptor 22; GPR22; MGC129847; Probable G-protein coupled receptor 22
Gene Symbols: GPR22
Molecular weight: 49,265 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene