APOOL Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function,. Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: X|X E1
Cellular Component:  integral component of membrane; membrane; MICOS complex; mitochondrion
Biological Process:  cristae formation
Reference #:  Q78IK4 (UniProtKB)
Alt. Names/Synonyms: 6720473G16Rik; 9430083G14Rik; apolipoprotein O-like; Apool; E130106L15Rik; Fam121a; MIC27; Mico; MICOS complex subunit Mic27; Micos27; OTTMUSP00000020016; Protein FAM121A
Gene Symbols: Apool
Molecular weight: 29,261 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene