CDK6 Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CDK4 subfamily; CDK4 subfamily; CMGC group; Cell cycle regulation; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 7q21.2
Cellular Component:  centrosome; cyclin D2-CDK6 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; nucleoplasm; nucleus; ruffle
Molecular Function:  ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; FBXO family protein binding; protein binding; protein serine kinase activity
Biological Process:  astrocyte development; cell dedifferentiation; cell division; dentate gyrus development; G1/S transition of mitotic cell cycle; generation of neurons; gliogenesis; hematopoietic stem cell differentiation; lateral ventricle development; negative regulation of cell cycle; negative regulation of cell differentiation; negative regulation of cell population proliferation; negative regulation of cellular senescence; negative regulation of epithelial cell proliferation; negative regulation of monocyte differentiation; negative regulation of myeloid cell differentiation; negative regulation of osteoblast differentiation; negative regulation of transcription by RNA polymerase II; Notch signaling pathway; positive regulation of cell-matrix adhesion; positive regulation of fibroblast proliferation; positive regulation of gene expression; protein phosphorylation; regulation of cell cycle; regulation of cell motility; regulation of erythrocyte differentiation; regulation of G2/M transition of mitotic cell cycle; regulation of gene expression; regulation of hematopoietic stem cell differentiation; response to organic substance; response to virus; signal transduction; T cell differentiation in thymus; type B pancreatic cell development
Disease: Microcephaly 12, Primary, Autosomal Recessive
Reference #:  Q00534 (UniProtKB)
Alt. Names/Synonyms: CDK6; CDKN6; Cell division protein kinase 6; cyclin dependent kinase 6; Cyclin-dependent kinase 6; MCPH12; MGC59692; PLSTIRE; Serine/threonine-protein kinase PLSTIRE
Gene Symbols: CDK6
Molecular weight: 36,938 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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