RGS11 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Chromosomal Location of Human Ortholog: 10q12
Cellular Component:  dendrite terminus; protein-containing complex
Molecular Function:  G-protein beta-subunit binding; GTPase activator activity
Biological Process:  negative regulation of signal transduction; positive regulation of GTPase activity; regulation of G protein-coupled receptor signaling pathway
Reference #:  XP_001062856 (RefSeq)
Alt. Names/Synonyms: Regulator of G-protein signaling 11; RGS11
Gene Symbols: Rgs11
Molecular weight: 53,737 Da
Basal Isoelectric point: 6.93  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
Select Structure to View Below

RGS11

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene