CHD-4 Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Belongs to the SNF2/RAD54 helicase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC 3.6.4.12; Helicase
Chromosomal Location of Human Ortholog: 4q42
Cellular Component:  centrosome; cytoplasm; nucleoplasm; nucleus; NuRD complex; protein-containing complex; protein-DNA complex
Molecular Function:  ATP binding; histone deacetylase binding; metal ion binding; RNA polymerase II repressing transcription factor binding; transcription factor binding
Biological Process:  negative regulation of transcription by RNA polymerase II; terminal button organization
Reference #:  E9PU01 (UniProtKB)
Alt. Names/Synonyms: CHD-4; Chd4; chromodomain helicase DNA binding protein 4; Chromodomain helicase DNA-binding protein 4; chromodomain-helicase-DNA-binding protein 4; Mi-2; Mi-2 autoantigen
Gene Symbols: Chd4
Molecular weight: 218,183 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CHD-4

Protein Structure Not Found.


Cross-references to other databases:  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein