KHS1 May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate. Note: This description may include information from UniProtKB.
Protein type: EC; KHS subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of rat Ortholog: 6q24
Cellular Component:  cytoplasm
Molecular Function:  ATP binding; MAP kinase kinase kinase kinase activity; protein serine/threonine kinase activity
Biological Process:  activation of MAPKKK activity; activation of protein kinase activity; intracellular signal transduction; MAPK cascade; protein phosphorylation; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  NP_001178945 (RefSeq)
Alt. Names/Synonyms: KHS1; Map4k5; mitogen-activated protein kinase kinase kinase kinase 5; RGD1562028
Gene Symbols: Map4k5
Molecular weight: 95,125 Da
Basal Isoelectric point: 8.12  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept  |  Ensembl Gene