SMC1B Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. Belongs to the SMC family. SMC1 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 7q34
Cellular Component:  chromosome, centromeric region; condensed nuclear chromosome; cytosol; lateral element; meiotic cohesin complex; nuclear meiotic cohesin complex; nucleoplasm; synaptonemal complex
Molecular Function:  ATP binding; DNA binding
Biological Process:  meiotic cell cycle; sister chromatid cohesion
Reference #:  NP_001123970 (RefSeq)
Alt. Names/Synonyms: SMC; Smc1b; Smc1l2; structural maintenace of chromosomes 1B; structural maintenance of chromosomes 1B
Gene Symbols: Smc1b
Molecular weight: 144,653 Da
Basal Isoelectric point: 6.83  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept  |  Ensembl Gene