CDC42EP3 Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Belongs to the BORG/CEP family. Highly expressed in the heart and weakly in the brain. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.
Chromosomal Location of Human Ortholog: 17|17 E3
Cellular Component:  actin cytoskeleton; cytoplasm; cytoskeleton; membrane; plasma membrane
Molecular Function:  GTP-Rho binding; protein binding
Biological Process:  positive regulation of actin filament polymerization; positive regulation of pseudopodium assembly; regulation of cell shape; Rho protein signal transduction
Reference #:  Q9CQC5 (UniProtKB)
Alt. Names/Synonyms: 3200001F04Rik; AA986861; Binder of Rho GTPases 2; Bor; Borg2; CDC42 effector protein (Rho GTPase binding) 3; Cdc42 effector protein 3; Cdc42ep3; Cep; Cep3; UB1
Gene Symbols: Cdc42ep3
Molecular weight: 27,686 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
Select Structure to View Below

CDC42EP3

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene