DNCLI2 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Belongs to the dynein light intermediate chain family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19p14
Cellular Component:  centrosome; cytoplasmic dynein complex; kinetochore; microtubule
Molecular Function:  ATP binding; dynein heavy chain binding; microtubule motor activity
Biological Process:  cellular response to nerve growth factor stimulus; centrosome localization; microtubule cytoskeleton organization; microtubule-based movement; protein homooligomerization
Reference #:  Q62698 (UniProtKB)
Alt. Names/Synonyms: Cytoplasmic dynein 1 light intermediate chain 2; DC1L2; Dncli2; Dync1li2; Dynein light intermediate chain 2, cytosolic; dynein, cytoplasmic 1 light intermediate chain 2; dynein, cytoplasmic, light intermediate polypeptide 2; LIC-2; LIC-2 dynein light intermediate chain 53/55; Lic2; LIC53/55; MGC108664
Gene Symbols: Dync1li2
Molecular weight: 54,745 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
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DNCLI2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene