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14-3-3 zeta
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity. Belongs to the 14-3-3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 7q22 |
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Cellular Component:
cell leading edge; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; mast cell granule; melanosome; mitochondrion; nucleus; perinuclear region of cytoplasm; postsynaptic density; protein-containing complex
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Molecular Function:
identical protein binding; ion channel binding; protein binding; protein domain specific binding; protein kinase binding; protein-containing complex binding; transcription factor binding; ubiquitin protein ligase binding
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Biological Process:
establishment of Golgi localization; Golgi reassembly; histamine secretion by mast cell; protein targeting; protein targeting to mitochondrion; regulation of cell death; regulation of synapse maturation; response to drug; synaptic target recognition
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Reference #:
P63102
(UniProtKB)
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Alt. Names/Synonyms: 14-3-3 protein zeta/delta; 14-3-3 zeta; 14-3-3z; 1433Z; KCIP-1; Mitochondrial import stimulation factor S1 subunit; Msfs1; Protein kinase C inhibitor protein 1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Ywhaz
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Gene Symbols: Ywhaz
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Molecular weight:
27,771 Da
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Basal Isoelectric point:
4.73
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Apoptosis Regulation
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G2/M DNA Damage Checkpoint
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Growth And Differentiation Control by MAPKs
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Hippo Signaling
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Mitochondrial Control of Apoptosis
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PI3K/Akt Signaling
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SAPK/JNK Signaling Cascades
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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