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AKR1B15
Isoform 1: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds. In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal. May play a physiological role in retinoid metabolism. Isoform 2: No oxidoreductase activity observed with the tested substrates. Belongs to the aldo/keto reductase family. Widely expressed. Expressed at highest levels in steroid-sensitive tissues, such as placenta, testis and adipose tissue. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.1.1.-; EC 1.1.1.21; EC 1.1.1.62; Oxidoreductase |
| Chromosomal Location of rat Ortholog: 4q22 |
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Cellular Component:
cytosol; mitochondrion
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Molecular Function:
alcohol dehydrogenase (NADP+) activity; alditol:NADP+ 1-oxidoreductase activity; oxidoreductase activity
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Biological Process:
oxidation-reduction process
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Reference #:
Q91W30
(UniProtKB)
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Alt. Names/Synonyms: AKR1B15; Akr1b8; aldo-keto reductase family 1, member B8; Aldose reductase-like protein; aldose reductase-related protein 2; MGC91427
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Gene Symbols: Akr1b8
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Molecular weight:
36,191 Da
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Basal Isoelectric point:
7.08
Predict pI for various phosphorylation states
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