GSTO1
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family. Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 1.20.4.2; EC 1.8.5.1; EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 |
Chromosomal Location of rat Ortholog: 1q54 |
Cellular Component:
axon; basement membrane; cell body; cytoplasm; cytosol; nuclear membrane
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Molecular Function:
glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; methylarsonate reductase activity; oxidoreductase activity
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Biological Process:
cellular oxidant detoxification; cellular response to arsenic-containing substance; glutathione metabolic process; L-ascorbic acid biosynthetic process; L-ascorbic acid metabolic process; negative regulation of ryanodine-sensitive calcium-release channel activity; positive regulation of ryanodine-sensitive calcium-release channel activity; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; xenobiotic catabolic process
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Reference #:
Q9Z339
(UniProtKB)
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Alt. Names/Synonyms: glutathione S-transferase omega 1; Glutathione S-transferase omega-1; Glutathione-dependent dehydroascorbate reductase; GSTO 1-1; GSTO-1; Gsto1; MGC94845
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Gene Symbols: Gsto1
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Molecular weight:
27,669 Da
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Basal Isoelectric point:
6.25
Predict pI for various phosphorylation states
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