CA2 Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Belongs to the alpha-carbonic anhydrase family. Note: This description may include information from UniProtKB.
Protein type: EC; Energy Metabolism - nitrogen; Lyase
Chromosomal Location of rat Ortholog: 2q23
Cellular Component:  apical part of cell; axon; basolateral plasma membrane; cytoplasm; cytosol; extracellular space; microvillus; myelin sheath; plasma membrane
Molecular Function:  arylesterase activity; carbonate dehydratase activity; protein binding; zinc ion binding
Biological Process:  angiotensin-activated signaling pathway; carbon dioxide transport; cellular response to fluid shear stress; kidney development; morphogenesis of an epithelium; odontogenesis of dentin-containing tooth; osteoclast differentiation; positive regulation of bone resorption; positive regulation of cellular pH reduction; positive regulation of dipeptide transmembrane transport; positive regulation of osteoclast differentiation; positive regulation of synaptic transmission, GABAergic; regulation of anion transport; regulation of bone resorption; regulation of cellular pH; regulation of chloride transport; regulation of intracellular pH; response to estrogen; response to organic substance; response to pH; response to steroid hormone; response to zinc ion; secretion
Reference #:  P27139 (UniProtKB)
Alt. Names/Synonyms: CA-II; Ca2; CAH2; Car2; Carbonate dehydratase II; Carbonic anhydrase 2; Carbonic anhydrase II
Gene Symbols: Car2
Molecular weight: 29,114 Da
Basal Isoelectric point: 6.89  Predict pI for various phosphorylation states
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Protein Structure Not Found.