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MCCC1
Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 6.4.1.4; Ligase; Mitochondrial |
| Chromosomal Location of rat Ortholog: 2q25 |
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Cellular Component:
3-methylcrotonyl-CoA carboxylase complex, mitochondrial; methylcrotonoyl-CoA carboxylase complex; mitochondrial matrix; mitochondrion
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Molecular Function:
ATP binding; ligase activity; metal ion binding; methylcrotonoyl-CoA carboxylase activity
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Biological Process:
carboxylic acid metabolic process; leucine catabolic process
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Reference #:
Q5I0C3
(UniProtKB)
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Alt. Names/Synonyms: 3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA carboxylase biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; Mcca; MCCase subunit alpha; Mccc1; Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; methylcrotonoyl-Coenzyme A carboxylase 1 (alpha); MGC95141
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Gene Symbols: Mccc1
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Molecular weight:
79,330 Da
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Basal Isoelectric point:
6.66
Predict pI for various phosphorylation states
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