MCCC1 Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC; Ligase; Mitochondrial
Chromosomal Location of rat Ortholog: 2q25
Cellular Component:  3-methylcrotonyl-CoA carboxylase complex, mitochondrial; methylcrotonoyl-CoA carboxylase complex; mitochondrial matrix; mitochondrion
Molecular Function:  ATP binding; ligase activity; metal ion binding; methylcrotonoyl-CoA carboxylase activity
Biological Process:  carboxylic acid metabolic process; leucine catabolic process
Reference #:  Q5I0C3 (UniProtKB)
Alt. Names/Synonyms: 3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA carboxylase biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; Mcca; MCCase subunit alpha; Mccc1; Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; methylcrotonoyl-Coenzyme A carboxylase 1 (alpha); MGC95141
Gene Symbols: Mccc1
Molecular weight: 79,330 Da
Basal Isoelectric point: 6.66  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene